Amanda-Jayne Carr

Lecturer and Principal Investigator


Curriculum vitae


[email protected]


University College London

Institute of Ophthalmology

11-43 Bath Street
London
EC1V 9EL



Publications


Translational readthrough as a potential therapeutic for AIPL1-associated Leber Congenital Amaurosis in a patient-derived iPSC-retinal organoid model


Amy Leung, Almudena Sacristan-Reviriego, Pedro R. L. Perdig{\~{a}}o, Hali Sai, Michalis Georgiou, Angelos Kalitzeos, Amanda-Jayne F. Carr, Peter J. Coffey, Michel Michaelides, James Bainbridge, Michael E. Cheetham, Jacqueline van der Spuy

Cold Spring Harbor Laboratory, 2021 Dec


Bestrophinopathies: perspectives on clinical disease, Bestrophin-1 function and developing therapies


Simranjeet Singh Grewal, Joseph J. Smith, Amanda-Jayne F. Carr

Therapeutic Advances in Ophthalmology, vol. 13, {SAGE} Publications, 2021 Jan, p. 251584142199719


Bestrophin1: A Gene that Causes Many Diseases


Joseph J. Smith, Britta Nommiste, Amanda-Jayne F. Carr

Retinal Degenerative Diseases, Springer International Publishing, 2019, pp. 419--423


Phenotypic and Functional Characterization of Müller Glia Isolated from Induced Pluripotent Stem Cell-Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation


Karen Eastlake, Weixin Wang, Hari Jayaram, Celia Murray-Dunning, Amanda J. F. Carr, Conor M. Ramsden, Anthony Vugler, Katrina Gore, Nadine Clemo, Mark Stewart, Pete Coffey, Peng T. Khaw, G. Astrid Limb

Stem Cells Translational Medicine, vol. 8, Oxford University Press ({OUP}), 2019 Apr, pp. 775--784


Phase 1 clinical study of an embryonic stem cell\textendashderived retinal pigment epithelium patch in age-related macular degeneration


Lyndon da Cruz, Kate Fynes, Odysseas Georgiadis, Julie Kerby, Yvonne H Luo, Ahmad Ahmado, Amanda Vernon, Julie T Daniels, Britta Nommiste, Shazeen M Hasan, Sakina B Gooljar, Amanda-Jayne F Carr, Anthony Vugler, Conor M Ramsden, Magda Bictash, Mike Fenster, Juliette Steer, Tricia Harbinson, Anna Wilbrey, Adnan Tufail, Gang Feng, Mark Whitlock, Anthony G Robson, Graham E Holder, Mandeep S Sagoo, Peter T Loudon, Paul Whiting, Peter J Coffey

Nature Biotechnology, vol. 36, Springer Science and Business Media {LLC}, 2018 Mar, pp. 328--337


Regulation of retinal pigment epithelial cell phenotype by Annexin A8


Katharina Lueck, Amanda-Jayne F. Carr, Dimitrios Stampoulis, Volker Gerke, Ursula Rescher, John Greenwood, Stephen E. Moss

Scientific Reports, vol. 7, Springer Science and Business Media {LLC}, 2017 Jul


Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs


Conor M. Ramsden, Britta Nommiste, Amelia R. Lane, Amanda-Jayne F. Carr, Michael B. Powner, Matthew J. K. Smart, Li Li Chen, Manickam N. Muthiah, Andrew R. Webster, Anthony T. Moore, Michael E. Cheetham, Lyndon da Cruz, Peter J. Coffey

Scientific Reports, vol. 7, Springer Science and Business Media {LLC}, 2017 Mar


Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC)


David A. Carter, Matthew J. K. Smart, William V. G. Letton, Conor M. Ramsden, Britta Nommiste, Li Li Chen, Kate Fynes, Manickam N. Muthiah, Pollyanna Goh, Amelia Lane, Michael B. Powner, Andrew R. Webster, Lyndon da Cruz, Anthony T. Moore, Peter J. Coffey, Amanda-Jayne F. Carr

Scientific Reports, vol. 6, Springer Science and Business Media {LLC}, 2016 Sep


Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups


David~A. Parfitt, Amelia Lane, Conor~M. Ramsden, Amanda-Jayne~F. Carr, Peter~M. Munro, Katarina Jovanovic, Nele Schwarz, Naheed Kanuga, Manickam~N. Muthiah, Sarah Hull, Jean-Marc Gallo, Lyndon da~Cruz, Anthony~T. Moore, Alison~J. Hardcastle, Peter~J. Coffey, Michael~E. Cheetham

Cell Stem Cell, vol. 18, Elsevier {BV}, 2016 Jun, pp. 769--781


Using Stem Cells to Model Diseases of the Outer Retina


Camille Yvon, Conor M. Ramsden, Amelia Lane, Michael B. Powner, Lyndon da Cruz, Peter J. Coffey, Amanda-Jayne F. Carr

Computational and Structural Biotechnology Journal, vol. 13, Elsevier {BV}, 2015, pp. 382--389


Engineering Efficient Retinal Pigment Epithelium Differentiation From Human Pluripotent Stem Cells


Amelia Lane, Lissa Rachel Philip, Ludmila Ruban, Kate Fynes, Matthew Smart, Amanda Carr, Chris Mason, Pete Coffey

Stem Cells Translational Medicine, vol. 3, Oxford University Press ({OUP}), 2014 Oct, pp. 1295--1304


Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells


Nele Schwarz, Amanda-Jayne Carr, Amelia Lane, Fabian Moeller, Li Li Chen, M{\`{o}}nica Aguil{\`{a}}, Britta Nommiste, Manickam N. Muthiah, Naheed Kanuga, Uwe Wolfrum, Kerstin Nagel-Wolfrum, Lyndon da Cruz, Peter J. Coffey, Michael E. Cheetham, Alison J. Hardcastle

Human Molecular Genetics, vol. 24, Oxford University Press ({OUP}), 2014 Oct, pp. 972--986


Development of human embryonic stem cell therapies for age-related macular degeneration


Amanda-Jayne F. Carr, Matthew J.K. Smart, Conor M. Ramsden, Michael B. Powner, Lyndon da Cruz, Peter J. Coffey

Trends in Neurosciences, vol. 36, Elsevier $\lbrace$BV$\rbrace$, 2013 Jul, pp. 385--395


Stem cells in retinal regeneration: past, present and future


C. M. Ramsden, M. B. Powner, A.-J. F. Carr, M. J. K. Smart, L. da Cruz, P. J. Coffey

Development, vol. 140, The Company of Biologists, 2013 May, pp. 2576--2585


Degeneration of cortical function in the Royal College of Surgeons rat


Carlos Gias, Anthony Vugler, Jean Lawrence, Amanda Jayne Carr, Li Li Chen, Ahmed Ahmado, Ma'ayan Semo, Peter J. Coffey

Vision Research, vol. 51, Elsevier $\lbrace$BV$\rbrace$, 2011 Oct, pp. 2176--2185


$\lbrace$iPS$\rbrace$ cells - an alternative source of $\lbrace$RPE$\rbrace$?


A CARR

Acta Ophthalmologica, vol. 89, Wiley-Blackwell, 2011 Sep, pp. 0--0


Induction of Differentiation by Pyruvate and $\lbrace$DMEM$\rbrace$ in the Human Retinal Pigment Epithelium Cell Line $\lbrace$ARPE$\rbrace$-19


A. Ahmado, A.-J. Carr, A. A. Vugler, M. Semo, C. Gias, J. M. Lawrence, L. L. Chen, F. K. Chen, P. Turowski, L. da Cruz, P. J. Coffey

Investigative Ophthalmology {\&} Visual Science, vol. 52, Association for Research in Vision and Ophthalmology ($\lbrace$ARVO$\rbrace$), 2011 Jul, pp. 7148--7159


Embryonic stem cells and retinal repair


Anthony Vugler, Jean Lawrence, James Walsh, Amanda Carr, Carlos Gias, Ma'ayan Semo, Ahmad Ahmado, Lyndon da Cruz, Peter Andrews, Peter Coffey

Mechanisms of Development, vol. 124, Elsevier $\lbrace$BV$\rbrace$, 2007 Nov, pp. 807--829


Light Reaches the Very Heart of the Zebrafish Clock


Amanda-Jayne F. Carr, T. Katherine Tamai, Lucy C. Young, Veronica Ferrer, Marcus P. Dekens, David Whitmore

Chronobiology International, vol. 23, Informa $\lbrace$UK$\rbrace$ Limited, 2006 Jan, pp. 91--100


Zebrafish circadian clocks: cells that see light


T.K. Tamai, A.J. Carr, D. Whitmore

Biochemical Society Transactions, vol. 33, Portland Press Ltd., 2005 Oct, p. 962


Imaging of single light-responsive clock cells reveals fluctuating free-running periods


Amanda-Jayne F. Carr, David Whitmore

Nat Cell Biol, vol. 7, Nature Publishing Group, 2005 Mar, pp. 319--321


Photoperiod Differentially Regulates Circadian Oscillators in Central and Peripheral Tissues of the Syrian Hamster


Amanda-Jayne F. Carr, Jonathan D. Johnston, Andrei G. Semikhodskii, Tania Nolan, Felino R.A. Cagampang, J.Anne Stirland, Andrew S.I. Loudon

Current Biology, vol. 13, Elsevier $\lbrace$BV$\rbrace$, 2003 Dec, p. 2124


Photoperiod Differentially Regulates Circadian Oscillators in Central and Peripheral Tissues of the Syrian Hamster


Amanda-Jayne F. Carr, Jonathan D. Johnston, Andrei G. Semikhodskii, Tania Nolan, Felino R.A. Cagampang, J.Anne Stirland, Andrew S.I. Loudon

Current Biology, vol. 13, Elsevier {BV}, 2003 Sep, pp. 1543--1548

Share



Follow this website


You need to create an Owlstown account to follow this website.


Sign up

Already an Owlstown member?

Log in