Translational readthrough as a potential therapeutic for AIPL1-associated Leber Congenital Amaurosis in a patient-derived iPSC-retinal organoid model

Amy Leung, Almudena Sacristan-Reviriego, Pedro R. L. Perdig{\~{a}}o, Hali Sai, Michalis Georgiou, Angelos Kalitzeos, Amanda-Jayne F. Carr, Peter J. Coffey, Michel Michaelides, James Bainbridge, Michael E. Cheetham, Jacqueline van der Spuy

Cold Spring Harbor Laboratory, 2021 Dec

Bestrophinopathies: perspectives on clinical disease, Bestrophin-1 function and developing therapies

Simranjeet Singh Grewal, Joseph J. Smith, Amanda-Jayne F. Carr

Therapeutic Advances in Ophthalmology, vol. 13, {SAGE} Publications, 2021 Jan, p. 251584142199719

Bestrophin1: A Gene that Causes Many Diseases

Joseph J. Smith, Britta Nommiste, Amanda-Jayne F. Carr

Retinal Degenerative Diseases, Springer International Publishing, 2019, pp. 419--423

Phenotypic and Functional Characterization of Müller Glia Isolated from Induced Pluripotent Stem Cell-Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation

Karen Eastlake, Weixin Wang, Hari Jayaram, Celia Murray-Dunning, Amanda J. F. Carr, Conor M. Ramsden, Anthony Vugler, Katrina Gore, Nadine Clemo, Mark Stewart, Pete Coffey, Peng T. Khaw, G. Astrid Limb

Stem Cells Translational Medicine, vol. 8, Oxford University Press ({OUP}), 2019 Apr, pp. 775--784

Phase 1 clinical study of an embryonic stem cell\textendashderived retinal pigment epithelium patch in age-related macular degeneration

Lyndon da Cruz, Kate Fynes, Odysseas Georgiadis, Julie Kerby, Yvonne H Luo, Ahmad Ahmado, Amanda Vernon, Julie T Daniels, Britta Nommiste, Shazeen M Hasan, Sakina B Gooljar, Amanda-Jayne F Carr, Anthony Vugler, Conor M Ramsden, Magda Bictash, Mike Fenster, Juliette Steer, Tricia Harbinson, Anna Wilbrey, Adnan Tufail, Gang Feng, Mark Whitlock, Anthony G Robson, Graham E Holder, Mandeep S Sagoo, Peter T Loudon, Paul Whiting, Peter J Coffey

Nature Biotechnology, vol. 36, Springer Science and Business Media {LLC}, 2018 Mar, pp. 328--337

Regulation of retinal pigment epithelial cell phenotype by Annexin A8

Katharina Lueck, Amanda-Jayne F. Carr, Dimitrios Stampoulis, Volker Gerke, Ursula Rescher, John Greenwood, Stephen E. Moss

Scientific Reports, vol. 7, Springer Science and Business Media {LLC}, 2017 Jul

Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs

Conor M. Ramsden, Britta Nommiste, Amelia R. Lane, Amanda-Jayne F. Carr, Michael B. Powner, Matthew J. K. Smart, Li Li Chen, Manickam N. Muthiah, Andrew R. Webster, Anthony T. Moore, Michael E. Cheetham, Lyndon da Cruz, Peter J. Coffey

Scientific Reports, vol. 7, Springer Science and Business Media {LLC}, 2017 Mar

Spontaneous Generation of Patient-Specific Retinal Pigment Epithelial Cells Using Induced Pluripotent Stem Cell Technology

Amanda-Jayne Carr

Working with Stem Cells, 2016

Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC)

David A. Carter, Matthew J. K. Smart, William V. G. Letton, Conor M. Ramsden, Britta Nommiste, Li Li Chen, Kate Fynes, Manickam N. Muthiah, Pollyanna Goh, Amelia Lane, Michael B. Powner, Andrew R. Webster, Lyndon da Cruz, Anthony T. Moore, Peter J. Coffey, Amanda-Jayne F. Carr

Scientific Reports, vol. 6, Springer Science and Business Media {LLC}, 2016 Sep

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups

David~A. Parfitt, Amelia Lane, Conor~M. Ramsden, Amanda-Jayne~F. Carr, Peter~M. Munro, Katarina Jovanovic, Nele Schwarz, Naheed Kanuga, Manickam~N. Muthiah, Sarah Hull, Jean-Marc Gallo, Lyndon da~Cruz, Anthony~T. Moore, Alison~J. Hardcastle, Peter~J. Coffey, Michael~E. Cheetham

Cell Stem Cell, vol. 18, Elsevier {BV}, 2016 Jun, pp. 769--781

Using Stem Cells to Model Diseases of the Outer Retina

Camille Yvon, Conor M. Ramsden, Amelia Lane, Michael B. Powner, Lyndon da Cruz, Peter J. Coffey, Amanda-Jayne F. Carr

Computational and Structural Biotechnology Journal, vol. 13, Elsevier {BV}, 2015, pp. 382--389

Neural retinal regeneration with pluripotent stem cells.

Amanda-Jayne Carr

2014

Engineering Efficient Retinal Pigment Epithelium Differentiation From Human Pluripotent Stem Cells

Amelia Lane, Lissa Rachel Philip, Ludmila Ruban, Kate Fynes, Matthew Smart, Amanda Carr, Chris Mason, Pete Coffey

Stem Cells Translational Medicine, vol. 3, Oxford University Press ({OUP}), 2014 Oct, pp. 1295--1304

Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells

Nele Schwarz, Amanda-Jayne Carr, Amelia Lane, Fabian Moeller, Li Li Chen, M{\`{o}}nica Aguil{\`{a}}, Britta Nommiste, Manickam N. Muthiah, Naheed Kanuga, Uwe Wolfrum, Kerstin Nagel-Wolfrum, Lyndon da Cruz, Peter J. Coffey, Michael E. Cheetham, Alison J. Hardcastle

Human Molecular Genetics, vol. 24, Oxford University Press ({OUP}), 2014 Oct, pp. 972--986

Development of human embryonic stem cell therapies for age-related macular degeneration

Amanda-Jayne F. Carr, Matthew J.K. Smart, Conor M. Ramsden, Michael B. Powner, Lyndon da Cruz, Peter J. Coffey

Trends in Neurosciences, vol. 36, Elsevier $\lbrace$BV$\rbrace$, 2013 Jul, pp. 385--395

Stem cells in retinal regeneration: past, present and future

C. M. Ramsden, M. B. Powner, A.-J. F. Carr, M. J. K. Smart, L. da Cruz, P. J. Coffey

Development, vol. 140, The Company of Biologists, 2013 May, pp. 2576--2585

The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide.

Amanda-Jayne Carr

2011

Degeneration of cortical function in the Royal College of Surgeons rat

Carlos Gias, Anthony Vugler, Jean Lawrence, Amanda Jayne Carr, Li Li Chen, Ahmed Ahmado, Ma'ayan Semo, Peter J. Coffey

Vision Research, vol. 51, Elsevier $\lbrace$BV$\rbrace$, 2011 Oct, pp. 2176--2185

$\lbrace$iPS$\rbrace$ cells - an alternative source of $\lbrace$RPE$\rbrace$?

A CARR

Acta Ophthalmologica, vol. 89, Wiley-Blackwell, 2011 Sep, pp. 0--0

Induction of Differentiation by Pyruvate and $\lbrace$DMEM$\rbrace$ in the Human Retinal Pigment Epithelium Cell Line $\lbrace$ARPE$\rbrace$-19

A. Ahmado, A.-J. Carr, A. A. Vugler, M. Semo, C. Gias, J. M. Lawrence, L. L. Chen, F. K. Chen, P. Turowski, L. da Cruz, P. J. Coffey

Investigative Ophthalmology {\&} Visual Science, vol. 52, Association for Research in Vision and Ophthalmology ($\lbrace$ARVO$\rbrace$), 2011 Jul, pp. 7148--7159

Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay.

Amanda-Jayne Carr

2009

Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat.

Amanda-Jayne Carr

2009

Embryonic stem cells and retinal repair

Anthony Vugler, Jean Lawrence, James Walsh, Amanda Carr, Carlos Gias, Ma'ayan Semo, Ahmad Ahmado, Lyndon da Cruz, Peter Andrews, Peter Coffey

Mechanisms of Development, vol. 124, Elsevier $\lbrace$BV$\rbrace$, 2007 Nov, pp. 807--829

Light Reaches the Very Heart of the Zebrafish Clock

Amanda-Jayne F. Carr, T. Katherine Tamai, Lucy C. Young, Veronica Ferrer, Marcus P. Dekens, David Whitmore

Chronobiology International, vol. 23, Informa $\lbrace$UK$\rbrace$ Limited, 2006 Jan, pp. 91--100

The tau mutation in the Syrian hamster differentially reprograms the circadian clock in the SCN and peripheral tissues.

Amanda-Jayne Carr

2005

The fish watch - zebrafish: a clock in every cell

Amanda-Jayne Carr

2005

Zebrafish circadian clocks: cells that see light

T.K. Tamai, A.J. Carr, D. Whitmore

Biochemical Society Transactions, vol. 33, Portland Press Ltd., 2005 Oct, p. 962

Imaging of single light-responsive clock cells reveals fluctuating free-running periods

Amanda-Jayne F. Carr, David Whitmore

Nat Cell Biol, vol. 7, Nature Publishing Group, 2005 Mar, pp. 319--321

Evidence for an endogenous per1- and ICER-independent seasonal timer in the hamster pituitary gland.

Amanda-Jayne Carr

2003

Photoperiod Differentially Regulates Circadian Oscillators in Central and Peripheral Tissues of the Syrian Hamster

Amanda-Jayne F. Carr, Jonathan D. Johnston, Andrei G. Semikhodskii, Tania Nolan, Felino R.A. Cagampang, J.Anne Stirland, Andrew S.I. Loudon

Current Biology, vol. 13, Elsevier $\lbrace$BV$\rbrace$, 2003 Dec, p. 2124

Photoperiod Differentially Regulates Circadian Oscillators in Central and Peripheral Tissues of the Syrian Hamster

Amanda-Jayne F. Carr, Jonathan D. Johnston, Andrei G. Semikhodskii, Tania Nolan, Felino R.A. Cagampang, J.Anne Stirland, Andrew S.I. Loudon

Current Biology, vol. 13, Elsevier {BV}, 2003 Sep, pp. 1543--1548